| Design | International RCT, n=6,104 |
| Published | 2009 (NEJM) |
| Result | Intensive glucose control (4.5–6.0 mmol/L) increased 90-day mortality (27.5% vs 24.9%) compared to conventional control (<10 mmol/L), with significantly more severe hypoglycaemia. |
| Practice impact | Changed practice globally; standard ICU glucose target is now 6–10 mmol/L. Tight glycaemic control is no longer recommended. |
Source: The Bottom Line