| Design | Canadian multicentre RCT, n=838 across 25 ICUs (TRICC) |
| Published | 1999 (NEJM) |
| Result | A restrictive transfusion threshold (Hb <7 g/dL) was non-inferior to a liberal threshold (<10 g/dL) for 30-day mortality. Liberal strategy was associated with more cardiac events. |
| Practice impact | Established the restrictive transfusion threshold as standard practice in general ICU patients; substantially reduced unnecessary blood transfusions worldwide. |
Source: The Bottom Line