| Design | 2×2 factorial multicentre double-blind RCT, n=409 |
| Published | 2016 (JAMA) |
| Result | Vasopressin did not improve kidney failure–free days compared to noradrenaline in septic shock. Less renal replacement therapy with vasopressin but no mortality benefit. No interaction with corticosteroids. |
| Practice impact | Vasopressin did not replace noradrenaline as a first-line agent; remains an adjunct to reduce noradrenaline requirements in refractory septic shock. |
Source: The Bottom Line